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Minomycin Prescribing Information

Minocycline Hydrochloride belongs to the class of tetracycline antibiotics. It is among the most lipid-soluble of all the tetracycline antibiotics and is also a bacteriostatic antibiotic. It provides the greatest penetration inside the brain and the prostrate, along with the greatest amount of side-effects affecting the Central Nervous System (CNS), like vertigo. It is usually orally administered. The drug isn't naturally found, but synthesized from natural tetracycline antibiotics. The trade name of minocycline hydrochloride is Minocin.

Minocycline Hydrochloride 50 mg

Uses of Minomycin

Here are some of the common uses of Minomycin:

Bacterial Infections: Minomycin is primarily used to treat a wide range of bacterial infections caused by susceptible organisms. These infections include:

  • Respiratory tract infections, such as pneumonia and bronchitis.
  • Skin and soft tissue infections, including acne, folliculitis, and cellulitis.
  • Urinary tract infections.
  • Sexually transmitted infections like chlamydia and gonorrhea.
  • Eye infections like conjunctivitis and other eye-related bacterial infections.

Acne: Medicine is frequently prescribed to manage moderate to severe cases of acne. Its anti-inflammatory properties in addition to its antibacterial effects can help reduce the inflammation associated with acne breakouts.

Rheumatoid Arthritis: Minomycin has been explored for its anti-inflammatory properties and has been used in some cases as an adjunct treatment for rheumatoid arthritis and other autoimmune conditions.

Periodontal Diseases: Antibiotic has shown potential in the treatment of certain periodontal diseases (diseases affecting the structures surrounding teeth) due to its ability to reduce the growth of bacteria responsible for these infections.

Lyme Disease: In some cases, drug can be used to treat early stages of Lyme disease, which is caused by the bacteria Borrelia burgdorferi.

Meningitis: Minomycin can be used as part of the treatment regimen for bacterial meningitis in specific cases.


The dosage of Minomycin can vary depending on the type and severity of the infection being treated, as well as individual patient factors such as age, weight, and medical history. The following dosages are general guidelines and should not replace the specific instructions provided by a healthcare professional. Always follow your doctor's recommendations and the instructions on the prescription label.

For Adults:

Bacterial Infections (General Dosage):

  • Initial dose: Usually, 200 mg as a single dose, followed by 100 mg every 12 hours.
  • Maintenance dose: After the initial dose, the maintenance dose is usually 100 mg every 12 hours.


  • Initial dose: 100 mg twice daily for 6 weeks.
  • Maintenance dose: After the initial period, the dose may be reduced to 50 mg twice daily.

Rheumatoid Arthritis:

  • The dosage for rheumatoid arthritis can vary, but it's typically higher than that used for bacterial infections. It may range from 100 mg to 200 mg twice daily.

For Children:

  • The dosage for children is usually determined by the child's weight. The doctor will calculate an appropriate dosage based on the child's weight and the specific condition being treated.

Important Notes:

  • Minomycin should be taken with a full glass of water and can be taken with or without food. However, taking it on an empty stomach may reduce the potential for stomach upset.
  • Do not take dairy products, antacids, or iron supplements within 2 hours of taking Minomycin, as they can interfere with its absorption.
  • It's important to complete the full course of treatment, even if symptoms improve before the medication is finished.
  • If you miss a dose, take it as soon as you remember. However, if it's close to the time for the next dose, skip the missed dose and continue with the regular dosing schedule.

Side Effects of Minomycin

Minomycin can potentially cause a range of side effects, which can vary in severity and frequency among individuals. Not everyone will experience these side effects, and some people may experience none at all. If you are prescribed Minocycline, it's important to be aware of potential side effects and to promptly report any unusual or severe symptoms to your healthcare provider. Common and less common side effects of Minomycin include:

Common Side Effects

  • Nausea and vomiting
  • Diarrhea or changes in bowel habits
  • Dizziness or lightheadedness
  • Headache
  • Tooth discoloration (especially in children)
  • Mouth or throat irritation
  • Photosensitivity (increased sensitivity to sunlight)
  • Skin rash or itching

Less Common or Serious Side Effects

  • Severe allergic reactions (rare but potentially serious)
  • Liver problems
  • Kidney problems
  • Intracranial hypertension (increased pressure inside the skull)
  • Blood disorders (such as decreased platelets or white blood cells)
  • Gastrointestinal problems (including inflammation of the pancreas)
  • Nervous system effects (including dizziness, confusion, or hallucinations)
  • Muscle or joint pain

Minomycin can also cause a condition known as drug-induced lupus-like syndrome, characterized by symptoms similar to systemic lupus erythematosus (SLE), such as joint pain, fever, and skin rash. This condition usually resolves after discontinuing the medication.

It's important to note that the list above is not exhaustive, and there can be other side effects as well. Additionally, some side effects may be specific to certain patient populations, such as pregnant women, children, or individuals with certain medical conditions.

Interaction with other drugs

Minocycline can interact with other drugs and substances, potentially affecting their effectiveness or increasing the risk of side effects. It's important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Minomycin. Here are some examples of interactions to be aware of:

  • Antacids and Supplements: Avoid taking antacids, calcium supplements, iron supplements, and magnesium-containing products within 2 hours of taking Minomycin, as they can reduce the absorption of the antibiotic.
  • Oral Contraceptives: Minocycline can reduce the effectiveness of oral contraceptives (birth control pills). Consider using additional contraceptive methods while taking Minomycin and for a short period after stopping it.
  • Blood-Thinning Medications (Warfarin): Minomycin can increase the effects of blood-thinning medications like warfarin, potentially increasing the risk of bleeding. Close monitoring of blood clotting times is important.
  • Isotretinoin: Using Minomycin along with isotretinoin (a medication for severe acne) can increase the risk of a condition called pseudotumor cerebri, which involves increased pressure in the skull.
  • Methotrexate: Medicine can increase the toxicity of methotrexate, a medication used for autoimmune conditions and cancer. Caution is needed if both drugs are used together.
  • Retinoids: Using Minomycin with retinoids (medications derived from vitamin A, often used for skin conditions) can increase the risk of intracranial hypertension.
  • Other Antibiotics and Antimicrobials: Taking multiple antibiotics together can sometimes increase the risk of side effects or reduce the effectiveness of either medication. If you're prescribed other antibiotics or antimicrobial agents, your doctor should be aware of the potential interactions.
  • Barbiturates and Anti-Seizure Medications: Some anti-seizure medications and barbiturates can reduce the effectiveness of Minomycin.
  • Live Bacterial Vaccines: Antibiotic might reduce the effectiveness of live bacterial vaccines. It's advisable to discuss vaccination schedules with your healthcare provider.
  • Alcohol: While there's no direct interaction between Minomycin and alcohol, consuming alcohol can exacerbate certain side effects like dizziness, nausea, and stomach upset.

What to avoid while on Minomycin

While taking Minomycin, there are certain things you should avoid to ensure the medication's effectiveness and reduce the risk of side effects. Here are some important considerations:

  • Dairy Products and Calcium-Rich Foods: Avoid consuming dairy products, calcium supplements, and other calcium-rich foods within 2 hours before or after taking Minomycin. Calcium can interfere with the absorption of the antibiotic, reducing its effectiveness.
  • Antacids, Iron Supplements, and Multivitamins: Similar to calcium, avoid taking antacids, iron supplements, and multivitamins containing minerals like zinc within 2 hours of taking Minomycin, as they can also interfere with absorption.
  • Direct Sunlight and Tanning Beds: Minocycline can make your skin more sensitive to sunlight, leading to an increased risk of sunburn and skin damage. It's important to use sunscreen, wear protective clothing, and avoid prolonged sun exposure and tanning beds while on Minomycin.
  • Alcohol: While there is no direct interaction between Minomycin and alcohol, alcohol consumption can exacerbate certain side effects like dizziness, nausea, and stomach upset. It's best to avoid excessive alcohol consumption during your treatment.
  • Other Antibiotics and Medications: If you're prescribed other antibiotics or medications, consult your healthcare provider about potential interactions. Using multiple medications together can sometimes lead to adverse effects or reduced effectiveness.
  • Oral Contraceptives: Drug can reduce the effectiveness of oral contraceptives (birth control pills). If you're using oral contraceptives for birth control, consider using additional contraceptive methods while taking Minomycin and for a short period after stopping it.
  • Retinoid Products: If you're using retinoid products for your skin (like tretinoin or isotretinoin), using them along with Minomycin can increase the risk of intracranial hypertension. Consult your doctor before using these products together.
  • Activities Requiring Mental Alertness: Some individuals may experience dizziness or lightheadedness while taking Minomycin. If you are affected, avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
  • High-Phosphorus Foods: In some cases, Minomycin can lead to increased levels of phosphorus in the blood. If your doctor advises, you might need to limit your intake of high-phosphorus foods.

Contraindications of Minomycin

Minocycline should not be taken under certain conditions or in combination with specific medical conditions or medications due to potential risks. Here are some contraindications and situations where Minomycin should be avoided:

  • Allergy to Tetracyclines: If you have a known allergy or hypersensitivity to tetracycline antibiotics, including minocycline, you should not take Minomycin.
  • Pregnancy and Breastfeeding: Medicine can affect fetal development and cause permanent discoloration of teeth in the developing baby. It is generally contraindicated during pregnancy, especially in the second and third trimesters. It should also be avoided while breastfeeding due to the potential for transfer to breast milk and potential harm to the infant.
  • Children Under 8 Years Old: Minomycin can cause permanent tooth discoloration and affect bone development in children under the age of 8. Therefore, it is generally not recommended for use in this age group.
  • Severe Liver or Kidney Disease: If you have severe liver or kidney disease, Minomycin should be used with caution or avoided, as it can further stress these organs and lead to complications.
  • Autoimmune Diseases: Minomycin may exacerbate autoimmune diseases like lupus. It should be used cautiously or avoided in individuals with autoimmune conditions.
  • Intracranial Hypertension: If you have a history of or are currently experiencing intracranial hypertension (increased pressure within the skull), Minomycin should be used with caution, as it can further increase pressure in the brain.
  • Myasthenia Gravis: Antibiotic can worsen the symptoms of myasthenia gravis, a neuromuscular disorder that leads to muscle weakness and fatigue.
  • Porphyria: Minomycin can trigger porphyria attacks in individuals with this rare genetic disorder that affects the production of heme, a component of hemoglobin.
  • Use of Isotretinoin: Using Minocycline concurrently with isotretinoin, a medication for severe acne, can increase the risk of a condition called pseudotumor cerebri, characterized by increased pressure in the skull.
  • Other Medication Interactions: Minomycin can interact with various medications, including anticoagulants, anti-seizure medications, and certain anti-acne medications. Your healthcare provider should assess potential interactions before prescribing Minomycin.

Hypersensitivity to Soy or Peanut: Minomycin capsules may contain soybean oil, and some formulations might contain peanut oil. Individuals with allergies to soy or peanuts should check with their healthcare provider before using this drug.

Pregnancy and Minomycin

Minomycin is generally contraindicated during pregnancy due to potential risks to the developing fetus. It is classified as a Category D medication by the U.S. Food and Drug Administration (FDA), indicating that there is evidence of risk to the fetus based on human studies or animal data.

Here are some reasons why Minomycin should be avoided during pregnancy:

  • Fetal Harm: Minocycline can cross the placental barrier and reach the developing fetus. There is a risk of causing harm to the fetus, including discoloration of teeth and inhibition of bone growth.
  • Permanent Tooth Discoloration: Minocycline can cause permanent yellow-gray-brown tooth discoloration in the developing baby if taken during pregnancy. This effect is particularly concerning when the drug is used in the second and third trimesters.
  • Bone Growth Inhibition: Minocycline can affect bone growth and development in the fetus, leading to potential skeletal abnormalities.
  • Liver Toxicity: There is a risk of hepatotoxicity (liver damage) associated with tetracycline antibiotics, including minocycline, in pregnant women.

Due to these risks, pregnant women are generally advised not to use Minomycin.

If you are sexually active and taking Minomycin, it's important to use effective contraception to prevent pregnancy while on the medication.

Drug Uses

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