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Cleocin Prescribing Information

Apart from all these bacterial diseases, Cleocin is also used to cure Anthrax and plague.

Cleocin was first introduced into the medical markets in 1967. It was first released in North America and has since spread all over the world and is easily available in most medical stores around the world. It is a WHO certified drug and is not extremely expensive. It is an affordable medication but prefer to buy with insurance.

Cleocin 150 mg

Cleocin is an antibiotic medication which is used to treat and cure the symptoms of numerous bacterial diseases. It has been seen that the medication is used to treat and cure the diseases which include stomach ulcers, bacterial infections, skin infections, Bronchitis and numerous other bacterial diseases.

Uses of Cleocin

Here are some common uses of Cleocin:

  • Bacterial Infections: Antibiotic is prescribed to treat various bacterial infections caused by susceptible bacteria. This includes skin and soft tissue infections, such as cellulitis and abscesses.
  • Respiratory Tract Infections: Cleocin can be used to treat respiratory tract infections like pneumonia, lung abscesses, and bronchitis, caused by susceptible bacteria.
  • Bone and Joint Infections: It can be used in the treatment of bone and joint infections, including osteomyelitis and septic arthritis.
  • Intra-Abdominal Infections: Cleocin may be prescribed to treat intra-abdominal infections like peritonitis and abscesses that result from bacterial contamination within the abdominal cavity.
  • Female Reproductive Tract Infections: This medication can also be used to treat infections of the female reproductive tract, such as pelvic inflammatory disease (PID) and infections following gynecological procedures.
  • Dental Infections: Cleocin can be used to treat dental infections, including tooth abscesses and other oral infections.
  • Bacterial Vaginosis: It may be used to treat bacterial vaginosis, a common vaginal infection caused by an imbalance of bacteria.
  • Acne: Medicine is sometimes used topically in the form of gels or creams to treat moderate to severe acne, particularly when other treatments have not been effective.
  • Malaria: In combination with quinine, Cleocin is used to treat certain types of malaria.
  • Preventing Infections: In some cases, Cleocin might be prescribed before certain surgeries or dental procedures to prevent bacterial infections.


The appropriate dosage of Cleocin can vary based on the type and severity of the infection, the patient's age, weight, renal function, and other factors. It's crucial to follow the dosage instructions provided by your healthcare provider or on the prescription label. Below are some general dosage guidelines for different forms of Cleocin:

Oral Cleocin (Clindamycin Capsules/Tablets):

  • Typical adult dosage for most infections: 150 to 450 mg every 6 hours.
  • Pediatric dosage: The dosage varies depending on the child's weight and the severity of the infection. Your doctor will determine the appropriate dose for your child.

Topical Cleocin (Clindamycin Cream/Gel):

  • For acne treatment: Apply a thin layer to the affected area(s) once or twice daily as directed by your healthcare provider.

IV Cleocin (Clindamycin Injection):

  • The dosage for IV administration depends on the type and severity of the infection.
  • Adult dosage: Typically ranges from 600 mg to 2.7 g per day, divided into 2 to 4 doses.
  • Pediatric dosage: Varies based on the child's weight and the specific infection being treated.

Crucial to complete the entire prescribed course of treatment, even if you start feeling better, to ensure that the infection is fully treated and to prevent the development of antibiotic resistance.

Side Effects of Cleocin

Cleocin is generally considered safe and effective when used as prescribed by a healthcare provider. However, like all medications, it can potentially cause side effects. Not everyone will experience these side effects, and they can range from mild to severe. Here are some common side effects associated with antibiotic:

Gastrointestinal Effects:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain or discomfort
  • Clostridium difficile-associated diarrhea (a severe and potentially life-threatening condition caused by overgrowth of certain bacteria in the colon)

Skin Reactions:

  • Skin rash
  • Itching
  • Allergic reactions, which can range from mild skin reactions to more severe reactions like swelling, difficulty breathing, and anaphylaxis

Liver Function:

  • Elevated liver enzymes (monitoring of liver function may be necessary)

Blood Disorders:

  • Decreased white blood cell count (leukopenia)
  • Decreased platelet count (thrombocytopenia)

Other Common Side Effects:

  • Pain or inflammation at the injection site (for IV use)
  • Esophagitis (inflammation of the esophagus, particularly when oral capsules/tablets are not taken with sufficient water and while remaining upright)
  • Metallic taste in the mouth

Rare but Serious Side Effects:

  • Severe allergic reactions (anaphylaxis)
  • Stevens-Johnson syndrome (a severe skin reaction)
  • Toxic epidermal necrolysis (a rare and serious skin condition)
  • Severe colitis (inflammation of the colon)
  • Liver toxicity

If you experience any severe or unusual side effects while taking Cleocin, it's important to seek medical attention immediately.

Interaction with other drug

Cleocin can interact with other drugs, potentially affecting their effectiveness or increasing the risk of side effects. It's important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Cleocin. Here are some notable drug interactions associated with Cleocin:

Drugs that Enhance Risk of Gastrointestinal Effects:

  • Other antibiotics, particularly those that affect gut bacteria
  • Proton pump inhibitors (PPIs) and H2 blockers used to reduce stomach acid (may increase the risk of Clostridium difficile-associated diarrhea)

Neuromuscular Blocking Agents:

  • Cleocin can enhance the effects of certain neuromuscular blocking agents used during surgery. This interaction could lead to prolonged muscle relaxation and potential respiratory issues.

Erythromycin and Other Macrolide Antibiotics:

  • Concurrent use of Cleocin and other macrolide antibiotics may lead to antagonistic effects.


  • Cleocin and lincomycin are structurally related antibiotics, and using them together could lead to an increased risk of adverse effects.

Certain Medications Metabolized by Liver Enzymes:

  • Medicine can affect the activity of liver enzymes that metabolize certain medications, potentially altering their blood levels. This might impact drugs like cyclosporine, theophylline, and certain anticoagulants.

Drugs that Affect Heart Rhythm (QT Prolongation):

  • Cleocin may increase the risk of QT interval prolongation when used concurrently with other medications that also have this potential effect, such as certain antiarrhythmics and antipsychotics.

Muscle Relaxants:

  • Cleocin might interact with certain muscle relaxants, leading to an increased risk of muscle weakness and potential respiratory issues.

Malaria Medications (e.g., Quinine):

  • Cleocin can interact with certain medications used to treat malaria, affecting their effectiveness.

What to avoid while on Cleocin

While taking Cleocin, there are certain things you should avoid to ensure the medication's effectiveness and reduce the risk of potential side effects. Here are some things to avoid:

  • Alcohol: It's generally advisable to avoid alcohol while taking antibiotics like Cleocin. Alcohol can potentially interfere with the absorption and metabolism of the medication, and it may also exacerbate certain side effects, such as gastrointestinal discomfort.
  • Other Antibiotics: Avoid taking other antibiotics simultaneously with Cleocin unless specifically directed by your healthcare provider. Concurrent use of certain antibiotics can lead to interactions or reduced effectiveness.
  • Antacids, Calcium Supplements, and Iron Supplements: Avoid taking these supplements within a few hours of Cleocin doses. They can bind to the medication and reduce its absorption, potentially making it less effective.
  • Dairy Products: Similar to antacids, calcium-rich dairy products (milk, yogurt, cheese) can interact with drug and reduce its absorption. It's best to space out dairy consumption from the time you take the medication.
  • Sun Exposure: Cleocin does not typically cause photosensitivity like some other antibiotics, but it's always a good practice to protect your skin from excessive sun exposure, especially if you're taking medications. If you notice any unusual skin reactions, consult your healthcare provider.
  • Neuromuscular Blocking Agents: If you are undergoing surgery or any medical procedure that involves the use of neuromuscular blocking agents (muscle relaxants), inform the medical team about your Cleocin use. Antibiotic can enhance the effects of these agents, potentially leading to prolonged muscle relaxation and respiratory issues.
  • Other Medications: Always consult your healthcare provider or pharmacist before starting any new medications, including over-the-counter drugs, herbal supplements, and vitamins. They can help you assess potential interactions and adjust your treatment plan if needed.
  • Dehydration: Antibiotic is associated with an increased risk of Clostridium difficile-associated diarrhea, which can be triggered by dehydration. Ensure you stay adequately hydrated while taking the medication.
  • Non-Prescription Pain Relievers: Certain non-prescription pain relievers (NSAIDs) can potentially interact with Cleocin or increase the risk of gastrointestinal irritation.

Contraindications of Cleocin

Cleocin has certain contraindications, which are situations or conditions where the use of the medication is not recommended due to the potential risks outweighing the benefits. It's important to inform your healthcare provider about your medical history and any pre-existing conditions before starting Cleocin. Here are some contraindications associated with this drug:

  • Hypersensitivity or Allergy: Antibiotic should not be used if you have a known hypersensitivity or allergy to clindamycin, lincomycin, or any other ingredients in the medication. Allergic reactions can range from mild skin rashes to severe anaphylaxis.
  • History of Colitis or Pseudomembranous Colitis: Cleocin can lead to Clostridium difficile-associated colitis, a potentially serious inflammation of the colon. If you have a history of colitis or pseudomembranous colitis, tablets should be used cautiously or avoided.
  • Severe Liver Disease: Individuals with severe liver disease may have difficulties metabolizing Cleocin properly, potentially leading to increased levels of the medication in the body. This can increase the risk of adverse effects.
  • Regional Enteritis (Crohn's Disease) or Ulcerative Colitis: Cleocin can worsen inflammatory bowel conditions like Crohn's disease and ulcerative colitis. It should be used with caution or avoided in individuals with these conditions.
  • Asthma or Atopy: Individuals with a history of asthma or atopic conditions (allergies, eczema) may be at an increased risk of severe allergic reactions to Cleocin.
  • Neuromuscular Disorders: Antibiotic can enhance the effects of neuromuscular blocking agents, potentially leading to prolonged muscle relaxation and respiratory issues. Individuals with certain neuromuscular disorders may be at a higher risk.
  • Pregnancy and Breastfeeding: The safety of Cleocin during pregnancy and breastfeeding has not been fully established. While Cleocin is generally considered safe during pregnancy, it should be used with caution and under the supervision of a healthcare provider.
  • Pediatric Use: Medicine should be used cautiously in infants and children due to the risk of developing severe colitis.
  • Renal Impairment: Tablets is primarily metabolized in the liver, but patients with severe renal impairment may require dosage adjustments. Consult your healthcare provider if you have kidney problems.
  • Seizure Disorders: Cleocin has been associated with an increased risk of seizures in some individuals. It should be used cautiously in patients with a history of seizure disorders.
  • Heart Conditions: Remedy can affect the heart's electrical activity (QT interval prolongation). If you have a history of heart rhythm disorders, consult your healthcare provider before using Cleocin.

Pregnancy and Cleocin

Cleocin is an antibiotic medication that is generally considered safe to use during pregnancy, but its use should be carefully considered and monitored under the guidance of a healthcare provider. The decision to use drug during pregnancy depends on the severity of the infection, potential risks, and benefits to both the pregnant person and the developing fetus.

Here are some key points to consider regarding the use of Cleocin during pregnancy:

  • Safety Profile: Pharmaceutical product is classified as a Category B medication by the U.S. Food and Drug Administration (FDA) for use during pregnancy. This means that animal studies have not shown a risk to the fetus, and there are no well-controlled studies in pregnant humans. However, the medication should be used only if the potential benefits outweigh the potential risks.
  • Infection Severity: In some cases, treating a bacterial infection with antibiotics like Cleocin is necessary to prevent complications that could harm both the pregnant person and the fetus. Untreated infections can pose risks during pregnancy, so the decision to use antibiotics is based on the infection's severity and potential impact on maternal and fetal health.
  • Consultation with Healthcare Provider: If you are pregnant or planning to become pregnant and your healthcare provider prescribes antibiotic, it's important to discuss the potential risks and benefits of the medication with them. They will consider your specific health situation and the type of infection being treated.
  • Dosage and Duration: Your healthcare provider will determine the appropriate dosage and duration of Cleocin treatment based on your individual needs. It's important to follow their instructions and complete the prescribed course of antibiotics.
  • Alternative Options: In some cases, there may be alternative antibiotics that are considered safer during pregnancy. Your healthcare provider will weigh the benefits and risks of each option to make an informed decision.
  • Breastfeeding: Cleocin can pass into breast milk, but the amount is generally considered low. If you are breastfeeding, discuss the potential risks and benefits with your healthcare provider. They can help you decide whether to continue breastfeeding or temporarily halt it while taking the medication.
Drug Uses

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