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Lincocin Prescribing Information

Lincocin is a brand name for the antibiotic medication lincomycin. Medicine is an antibiotic that belongs to the class of drugs known as lincosamides. It is used to treat various bacterial infections caused by susceptible bacteria. Lincomycin works by inhibiting bacterial protein synthesis, which ultimately leads to the suppression of bacterial growth and multiplication.

Antibiotic is primarily used to treat infections caused by anaerobic bacteria and gram-positive bacteria. It's often prescribed in cases where other antibiotics might be ineffective due to bacterial resistance or allergies to other antibiotic classes.

Lincocin capsules

Uses of Lincocin

Lincocin is used to treat a variety of bacterial infections caused by susceptible bacteria. Some common uses include:

  • Infections of the Skin and Soft Tissues: Antibiotic can be used to treat infections of the skin, subcutaneous tissues, and other soft tissues caused by susceptible bacteria. This includes conditions like cellulitis, abscesses, and wound infections.
  • Respiratory Tract Infections: It can be prescribed for respiratory tract infections such as pneumonia, bronchitis, and lung abscesses caused by bacteria susceptible to lincomycin.
  • Bone and Joint Infections: Lincocin might be used to treat bone and joint infections, including osteomyelitis and septic arthritis, when the causative bacteria are susceptible to the drug.
  • Intra-abdominal Infections: In some cases, Lincocin can be considered for treating intra-abdominal infections like peritonitis and abscesses caused by susceptible bacteria.
  • Bacterial Septicemia: It can be used in cases of bacterial bloodstream infections or septicemia caused by bacteria susceptible to lincomycin.
  • Other Infections: Drug might also be considered for other types of infections, depending on the susceptibility of the causative bacteria. This could include infections of the female reproductive tract, pelvic inflammatory disease, and more.

It's important to note that Lincocin is generally reserved for infections caused by bacteria that are susceptible to its action. Bacterial cultures and susceptibility tests are often performed to determine if this medicine is an appropriate treatment choice for a specific infection.


The dosage of Lincocin can vary depending on factors such as the type of infection, the severity of the infection, the patient's age and weight, and their overall health condition. Some general dosing guidelines:

Lincocin Capsules:

  • Adults: The typical dose for adults is usually 500 mg to 1 g every 8 to 12 hours. The maximum daily dose is typically around 8 g.
  • Children: The dose for children is usually based on their weight and the severity of the infection. The recommended dose is around 10 to 20 mg per kg of body weight per day, divided into multiple doses.

Lincocin Injection:

  • Lincocin is also available in an injectable form, often administered intramuscularly (into a muscle) or intravenously (into a vein). The dosage can vary based on the same factors mentioned above.

It's important to complete the full course of treatment, even if your symptoms improve before the course is finished. Stopping the medication prematurely can lead to the development of antibiotic-resistant bacteria.

Side Effects of Lincocin

Lincocin is an antibiotic medication that can have potential side effects. Not everyone will experience these side effects, and some individuals may experience them to a varying degree of severity. Common and less common side effects include:

Common Side Effects:

  • Upset stomach, nausea, vomiting
  • Diarrhea
  • Abdominal pain or discomfort
  • Skin rash or itching
  • Pain, swelling, or redness at the injection site (if given as an injection)
  • Changes in taste perception

Less Common Side Effects:

  • Severe allergic reactions (difficulty breathing, hives, swelling of the face, lips, tongue, or throat)
  • Severe skin reactions (rash, blistering, peeling, or redness)
  • Blood disorders (unexplained bruising, bleeding, pale skin, weakness)
  • Severe diarrhea (which could indicate a more serious condition known as pseudomembranous colitis)
  • Liver problems (yellowing of the skin or eyes, dark urine, persistent nausea or vomiting, abdominal pain)
  • Muscle weakness or pain
  • Difficulty swallowing or breathing

It's important to note that some side effects, like severe diarrhea or allergic reactions, can be serious and require immediate medical attention. If you experience any of these severe symptoms, you should seek medical help right away.

Interaction with other drugs

Lincocin can interact with other drugs, potentially affecting their effectiveness, increasing the risk of side effects, or altering the way they are metabolized in the body. Here are some examples of drug interactions that can occur:

  • Neuromuscular Blocking Agents: Lincocin can enhance the effects of neuromuscular blocking agents, which are used during surgery to relax muscles. This can lead to prolonged muscle paralysis and respiratory depression. It's important to inform your anesthesiologist if you are taking Lincocin before any surgical procedures.
  • Other Antibiotics: Concurrent use of other antibiotics, particularly those that work through a similar mechanism, may result in reduced effectiveness or an increased risk of side effects.
  • Clindamycin: Lincomycin and clindamycin are related antibiotics, and using them together can increase the risk of side effects.
  • Erythromycin: Combining Lincocin with erythromycin, another antibiotic, can lead to a reduced efficacy of both drugs.
  • Vaccines: Lincocin might interfere with the effectiveness of certain vaccines.
  • Antagonistic Drugs: Some drugs that affect gastrointestinal motility (movement) can reduce the absorption of Lincocin when taken together, potentially reducing its effectiveness.
  • Anticoagulants: Antibiotic might enhance the effects of anticoagulant medications, increasing the risk of bleeding.
  • Medications that Affect Liver Enzymes: Drug can influence liver enzyme activity, potentially affecting the metabolism of other drugs that are processed in the liver.

What to avoid while on Lincocin

While taking Lincocin, there are certain things you should avoid or be cautious about to ensure the safety and effectiveness of your treatment. Here are some guidelines to consider:

  • Alcohol: It's generally recommended to avoid alcohol while on antibiotics. Alcohol can potentially interact with the medication, affect its metabolism, and increase the risk of side effects. Additionally, alcohol consumption can weaken the immune system and interfere with the body's ability to fight infections.
  • Neuromuscular Blocking Agents: Avoid using neuromuscular blocking agents, which are used during surgical procedures to relax muscles. Combining Lincocin with these agents can lead to prolonged muscle paralysis and respiratory depression.
  • Other Antibiotics: Be cautious when taking other antibiotics alongside Lincocin. Combining certain antibiotics can lead to reduced effectiveness or increased risk of side effects.
  • Antagonistic Drugs: Drugs that affect gastrointestinal motility (movement) might reduce the absorption of Lincocin.
  • Anticoagulants: If you're on anticoagulant medications (blood thinners), be cautious, as Lincocin might enhance the effects of these drugs and increase the risk of bleeding.
  • High-Calcium Foods and Supplements: Lincocin's absorption can be impaired by foods and supplements high in calcium. It's recommended to avoid consuming large amounts of calcium-rich foods or supplements close to the time you take capsules.
  • Driving and Operating Machinery: Drug may cause dizziness, drowsiness, or confusion in some individuals. If you experience these side effects, avoid activities that require mental alertness, such as driving or operating heavy machinery.
  • Allergies and Sensitivities: If you have a known allergy to lincomycin or any other ingredients in Lincocin, it's essential to avoid taking this medication and inform your doctor.

Contraindications of Lincocin

Contraindications are specific conditions or situations in which a medication should not be used due to potential risks or lack of effectiveness. Here are some contraindications and situations where should generally be avoided:

  • Hypersensitivity or Allergy: If you have a known hypersensitivity or allergy to lincomycin or any of its components, you should not take Lincocin.
  • History of Severe Gastrointestinal Disease: Lincocin can cause a condition called pseudomembranous colitis, which is a severe inflammation of the colon. If you have a history of colitis, gastrointestinal disease, or a previous episode of pseudomembranous colitis associated with antibiotic use, capsules should be used with caution.
  • Myasthenia Gravis: Myasthenia gravis is a neuromuscular disorder characterized by muscle weakness. Lincocin can potentially exacerbate this condition due to its effects on neuromuscular function.
  • Neuromuscular Disorders: Antibiotic can enhance the effects of neuromuscular blocking agents, which are used during surgery to relax muscles. This can lead to prolonged muscle paralysis and respiratory depression. Therefore, Lincocin should be avoided in individuals with certain neuromuscular disorders.
  • Liver Impairment: Individuals with severe liver impairment may require dosage adjustments or should avoid Lincocin altogether, as the medication is metabolized in the liver.
  • Children Under 1 Month: Medicine is generally not recommended for use in infants younger than 1 month old due to the potential risk of developing serious side effects.
  • Elderly Patients: While not a strict contraindication, caution is advised when prescribing Lincocin to elderly patients due to potential changes in kidney and liver function that can affect drug metabolism.

Pregnancy and Lincocin

Lincocin use during pregnancy is generally not recommended unless the potential benefits of treatment outweigh the potential risks to the developing fetus.

Here are some points to consider regarding this medicament use during pregnancy:

  • Fetal Development: Limited human data are available regarding the use of Lincocin during pregnancy. Animal studies have shown some evidence of adverse effects on fetal development, so caution is advised.
  • Pregnancy Trimester: The potential risks and benefits of using Lincocin can vary based on the specific trimester of pregnancy.
  • Breastfeeding: Lincocin can potentially pass into breast milk, so it's important to discuss breastfeeding plans with your doctor.
  • Individual Assessment: Each pregnancy is unique, and decisions about medication use should be made on an individual basis.
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