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Ilosone Prescribing Information

Ilosone or Erythromycin belongs to a group of medications which are known as macrolide antibiotics. Basically, these medications are known to fight the symptoms of bacterial cells in the body. Apart from most of the bacterial infections, Ilosone is also used to cure numerous other diseases such as Bronchitis, stomach ulcer, diarrhea, loose motions as well as various joint pains.

Ilosone 250 mg

However, one of the most important things which one should notice about an antibiotic is that it is only responsible for the treatment of the diseases which are caused due to bacterial cells. If you consume antibiotic meds to cure the viral diseases, you will not get any kind of relief and it might also make the situation even worse.

Although this kind of antibiotic medications treat a group of Diseases which are best known to everybody, yet, it has been seen that there are numerous other diseases which can be cured with the help of such antibiotics; but are not mentioned on the prescription label of the medication.

Uses of Ilosone

Medicine belongs to a class of antibiotics known as macrolides, and it has a broad spectrum of activity against various bacteria. Here are some common uses:

  • Bacterial Infections: Antibiotic is often prescribed to treat a wide range of bacterial infections, including respiratory tract infections (such as pneumonia, bronchitis, and sinusitis), skin and soft tissue infections, ear infections, and certain sexually transmitted infections like chlamydia.
  • Gastrointestinal Infections: Ilosone can be used to treat infections caused by certain bacteria in the gastrointestinal tract. It is sometimes prescribed for conditions like bacterial gastroenteritis, including those caused by Campylobacter and Legionella species.
  • Acne: Remedy is sometimes used topically in the form of a gel or lotion to treat mild to moderate acne. It helps reduce the growth of bacteria on the skin and can be used in combination with other acne treatments.
  • Prophylaxis: Erythromycin might be used as a prophylactic (preventive) treatment for individuals who are at risk of bacterial endocarditis, an infection of the inner lining of the heart, before certain dental or medical procedures.
  • Pregnancy: Medicine can be used during pregnancy to treat certain infections that are safe for both the mother and the baby, since some other antibiotics might pose risks to the developing fetus.
  • Preterm Labor: In some cases, Ilosone might be prescribed to pregnant women to prevent preterm labor or to reduce the risk of certain complications.

It's important to note that the use of antibiotics should be based on proper medical assessment and diagnosis. Overuse or misuse of antibiotics can lead to antibiotic resistance, where bacteria become less responsive to the drugs over time.


The dosage of Ilosone can vary depending on the specific infection being treated, the age and weight of the patient, and other factors. It's important to follow your doctor's instructions and the dosing guidelines provided on the prescription label. The following information provides a general overview of Ilosone dosages for some common indications:

Bacterial Infections:

  • Adults: The typical oral dosage for adults is 250-500 mg every 6 hours or 500-1000 mg every 12 hours. The maximum daily dosage is usually 4 grams.
  • Children: The dosage for children varies based on their weight. It's usually around 30-50 mg/kg per day, divided into multiple doses.

Acne (Topical):

  • Ilosone topical solutions or gels are typically applied to the affected area twice daily.

Prophylaxis for Bacterial Endocarditis:

  • Adults: A single dose of 1 gram of Ilosone is often recommended one hour before a dental or medical procedure that might cause bleeding.

Gastrointestinal Infections:

  • Dosages can vary depending on the specific type and severity of the infection. Your doctor will determine the appropriate dosage for your condition.

Other Indications:

  • Dosages for other uses, such as for preterm labor or certain pediatric infections, will be determined by the prescribing healthcare provider.

It's crucial to complete the full course of treatment, even if your symptoms improve before the medication is finished. If you miss a dose, take it as soon as you remember, but do not take two doses at the same time.

Side Effects of Ilosone

Ilosone is generally well-tolerated by most individuals, but like any medication, it can have potential side effects. Common and less serious side effects might include:

Gastrointestinal Distress:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Upset stomach

Allergic Reactions:

  • Rash
  • Itching
  • Hives
  • Swelling (especially of the face, lips, or tongue)
  • Difficulty breathing

Skin Reactions:

  • Skin rash
  • Photosensitivity (increased sensitivity to sunlight)
  • Skin peeling or blistering

Other Common Side Effects:

  • Vaginal itching or discharge (in females)
  • Changes in taste
  • Dizziness
  • Headache

In some cases, Ilosone can lead to more serious side effects. If you experience any of the following symptoms, you should seek medical attention immediately:

Severe Allergic Reaction:

  • Difficulty breathing or swallowing
  • Swelling of the face, lips, or throat
  • Rapid heartbeat
  • Fainting

Severe Gastrointestinal Effects:

  • Severe or persistent diarrhea
  • Abdominal cramps or pain
  • Blood or mucus in the stool

Liver Problems:

  • Yellowing of the skin or eyes (jaundice)
  • Dark urine
  • Unusual fatigue or weakness

Irregular Heartbeat (Arrhythmia):

  • Palpitations
  • Fainting

Serious Skin Reactions:

  • Severe skin rash
  • Blisters or peeling skin
  • Fever
  • Joint pain

It's important to note that this list is not exhaustive, and not everyone will experience these side effects. Some individuals may not experience any side effects at all. If you are concerned about the potential side effects of Ilosone or are experiencing any unusual symptoms while taking the medication, you should contact your healthcare provider for guidance. Additionally, if you have a history of allergies or other medical conditions, make sure to inform your doctor before starting any new medication.

Interaction with other drugs

Ilosone can interact with other drugs, potentially affecting their effectiveness or causing adverse effects. It's important to inform your healthcare provider about all the medications, supplements, and herbal products you are taking before starting Ilosone. Here are some notable drug interactions:

Drugs that Increase the Risk of Arrhythmias (Abnormal Heart Rhythms):

  • Ilosone can interact with medications that prolong the QT interval (a measure of heart rhythm) and increase the risk of arrhythmias. These include certain antipsychotic drugs, certain antiarrhythmic drugs, and some antibiotics.

CYP3A4 Inhibitors:

  • Drug is a moderate to strong inhibitor of the CYP3A4 enzyme, which is involved in the metabolism of many drugs. Taking Ilosone with medications metabolized by CYP3A4 can lead to increased levels of these drugs in the body. This can lead to enhanced effects or increased risk of side effects. Common examples include:
  • Certain statins (cholesterol-lowering drugs)
  • Some antiarrhythmic drugs
  • Certain antihistamines
  • Some antiretroviral drugs used to treat HIV

Warfarin and Other Blood Thinners:

  • Ilosone can interact with warfarin and other blood-thinning medications, potentially leading to an increased risk of bleeding.

Theophylline and Caffeine:

  • Pharmaceutical product can increase blood levels of theophylline (used to treat asthma and other respiratory conditions) and caffeine, potentially leading to increased side effects.


  • Ilosone can increase the levels of digoxin (used to treat heart failure and certain heart rhythm problems), leading to digoxin toxicity.

Medications Metabolized by CYP3A4:

  • Antibiotic can impact the metabolism of various drugs. Therefore, it's important to consult your healthcare provider before combining Ilosone with medications metabolized by CYP3A4.

Medications for Erectile Dysfunction (PDE5 Inhibitors):

  • Combining Ilosone with PDE5 inhibitors (such as sildenafil, tadalafil, or vardenafil) used to treat erectile dysfunction can lead to a dangerous drop in blood pressure.

Antacids and Acid-Suppressing Drugs:

  • Antacids and acid-suppressing drugs can reduce the absorption of Erythromycin, potentially making it less effective. These medications should be taken at least 2 hours before or after Ilosone.

What to avoid while on Ilosone

While taking Ilosone, there are certain things you should avoid to ensure the medication's effectiveness and minimize the risk of potential interactions or side effects. Here are some things to avoid:

Grapefruit and Grapefruit Juice:

  • Grapefruit and grapefruit juice can interact with Ilosone and affect its metabolism, potentially leading to increased levels of the medication in your body. This can increase the risk of side effects.


  • Drinking alcohol while taking Ilosone can increase the risk of certain side effects, including gastrointestinal upset. Additionally, alcohol consumption might interfere with your body's ability to fight off the infection you're being treated for.

Acid-Reducing Medications:

  • Antacids, proton pump inhibitors (PPIs), and H2 blockers can reduce the absorption of Ilosone. To ensure the medication is properly absorbed, take it at least 2 hours before or after taking these acid-reducing medications.

Medications with Known Interactions:

  • Avoid taking medications that are known to interact with Ilosone without consulting your healthcare provider first. This includes drugs that can prolong the QT interval, CYP3A4 inhibitors, and medications that have been specifically flagged for interaction.

Over-the-Counter Supplements and Herbal Products:

  • Some herbal products and dietary supplements can interact with medications, including Ilosone. It's important to discuss the use of any supplements with your healthcare provider to avoid potential interactions.

Driving and Operating Heavy Machinery:

  • Medicine might cause dizziness, fatigue, or other side effects that could impair your ability to drive or operate machinery safely. If you experience these effects, avoid such activities until you know how the medication affects you.

Sun Exposure and Tanning Beds:

  • Ilosone can make your skin more sensitive to sunlight. Avoid prolonged sun exposure and tanning beds while on the medication. If you need to be outside, use sunscreen and protective clothing.

Other Antibiotics:

  • Avoid using other antibiotics without consulting your healthcare provider, as they might interact or interfere with the efficacy of Ilosone.

Contraindications of Ilosone

Contraindications are specific situations, conditions, or factors that make the use of a particular medication, such as Ilosone, potentially unsafe or inadvisable. It's important to be aware of contraindications to ensure your safety and the effectiveness of the medication. Here are some contraindications:

Hypersensitivity to Ilosone:

  • If you have a known allergy or hypersensitivity to Ilosone or any of its components, you should not use this drug.

Concomitant Use with Strong CYP3A4 Inhibitors:

  • Ilosone is metabolized by the CYP3A4 enzyme. Concurrent use of strong CYP3A4 inhibitors (medications that significantly decrease the activity of this enzyme) can lead to increased levels of Ilosone in the body, potentially causing adverse effects.

Concomitant Use with Certain Medications that Prolong the QT Interval:

  • Medicine can also affect the heart's electrical activity and lead to QT interval prolongation. Combining Ilosone with other medications known to prolong the QT interval can increase the risk of serious arrhythmias.

History of Ventricular Arrhythmias or Sudden Cardiac Death:

  • If you have a history of certain types of heart arrhythmias or sudden cardiac death, the use of Ilosone might not be recommended due to its potential to affect heart rhythm.

History of Liver Dysfunction:

  • If you have a history of severe liver dysfunction or certain liver conditions, your healthcare provider might need to adjust the dose or avoid the use of Ilosone due to the risk of further liver damage.

Myasthenia Gravis:

  • Myasthenia gravis is a neuromuscular disorder that causes muscle weakness. Ilosone can exacerbate the symptoms of myasthenia gravis, so its use might be contraindicated in individuals with this condition.

Breastfeeding Mothers:

  • Ilosone is excreted in breast milk, and there is a potential for it to affect nursing infants. Breastfeeding mothers should consult their healthcare providers before using drug.

Certain Concomitant Medications:

  • Ilosone can interact with various medications, so its use might be contraindicated when used concurrently with certain drugs that can lead to serious interactions or adverse effects.

It's important to note that this list is not exhaustive, and contraindications can vary based on individual medical history and circumstances.

Pregnancy and Ilosone

Ilosone is generally considered safe for use during pregnancy, but as with any medication, it should be used under the guidance and supervision of a healthcare provider. Pregnant individuals should consult their doctor before starting any new medication, including Ilosone, to ensure that the potential benefits outweigh any potential risks. Here's some information about the use of this medicine during pregnancy:

  • Safety Profile: Antibiotic is generally considered a safe option for treating bacterial infections during pregnancy. It belongs to the macrolide class of antibiotics, and studies have not shown a significant increase in the risk of birth defects or other adverse outcomes when used during pregnancy.
  • Infections: Ilosone can be used to treat various bacterial infections that might occur during pregnancy, such as respiratory infections, skin infections, and certain sexually transmitted infections.
  • Preterm Labor: Medicine is sometimes used as a preventive treatment for preterm labor. It can be given to pregnant individuals with certain risk factors to reduce the risk of premature birth.
  • Chlamydia and Gonorrhea Treatment: Drug is one of the antibiotics used to treat chlamydia and gonorrhea, which are sexually transmitted infections that can affect pregnant individuals. Treating these infections during pregnancy is important to prevent potential complications.
  • Topical Use for Acne: Topical Ilosone is sometimes used to treat acne during pregnancy. However, it's important to discuss the use of any topical medications with your healthcare provider.
  • Consult Your Doctor: Pregnant individuals should always consult their healthcare provider before taking any medication, including Erythromycin. The decision to use any medication during pregnancy should be based on a careful assessment of the potential benefits and risks, taking into consideration the specific circumstances of the individual.
  • Dosage and Duration: Your doctor will determine the appropriate dosage and duration of treatment based on the type of infection, the severity of the condition, and your medical history.
  • Breastfeeding: Ilosone is excreted in breast milk, but it is generally considered safe for breastfeeding mothers. However, it's important to discuss its use with your healthcare provider if you are breastfeeding.
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