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Fusiderm Prescribing Information

Fusiderm is a brand name for a topical medication that contains two active ingredients: fusidic acid and betamethasone. It is primarily used for treating various skin conditions, particularly those involving inflammation and bacterial infection. Here's a bit more detail about each of the active ingredients:

  • Fusidic Acid: Fusidic acid is an antibiotic that is effective against a range of bacteria, particularly Staphylococcus species. It works by inhibiting bacterial protein synthesis, which helps to control and treat bacterial infections on the skin.
  • Betamethasone: Betamethasone is a corticosteroid, which is a type of anti-inflammatory medication. It works by reducing inflammation, redness, and itching associated with various skin conditions. It does this by suppressing the immune response and reducing the release of inflammatory substances.

Fusiderm is commonly prescribed for conditions such as infected eczema, dermatitis, impetigo, and other skin infections that are susceptible to the antibiotic properties of fusidic acid. The addition of betamethasone helps to address the inflammatory component of these conditions.

Fusiderm cream

Uses of Fusiderm

Fusiderm, a combination medication containing fusidic acid and betamethasone, is primarily used for the treatment of various skin conditions that involve both bacterial infection and inflammation. Some common uses of Fusiderm include:

  • Infected Dermatitis or Eczema: Remedy can be prescribed to treat cases of dermatitis or eczema that have become infected with bacteria. It helps to control the infection while also reducing inflammation and relieving itching and redness.
  • Impetigo: Impetigo is a highly contagious bacterial skin infection that often affects children. Fusiderm can be used to treat mild to moderate cases of impetigo by targeting the bacterial infection and addressing the associated inflammation.
  • Folliculitis: This is an infection of hair follicles that can cause redness, itching, and pustules. Medicine can be used to treat folliculitis, particularly if it is caused by bacteria susceptible to fusidic acid.
  • Secondary Skin Infections: Fusiderm can be prescribed for treating secondary bacterial infections that occur in wounds, cuts, or other skin injuries.
  • Intertrigo: Intertrigo is a rash that occurs in skin folds due to friction, moisture, and bacterial or fungal growth. Fusiderm can help treat intertrigo by addressing both the infection and inflammation.
  • Other Skin Infections: Fusiderm may also be used for other skin infections caused by bacteria that are sensitive to fusidic acid.

Prolonged or improper use of corticosteroids like betamethasone can lead to adverse effects, including skin thinning and increased susceptibility to infections. It's also important to follow the prescribed dosage and duration of treatment to avoid potential side effects and the development of antibiotic resistance.


The dosage of Fusiderm can vary based on the specific formulation, the severity of the condition being treated, and the guidance of the prescribing healthcare professional. It's important to follow your doctor's instructions and the dosage information provided on the medication packaging. Here is a general guideline, but remember that this is not a substitute for professional medical advice:

Fusiderm Cream or Ointment:

  • The cream or ointment should be applied thinly and evenly to the affected area of skin.
  • The typical recommended frequency of application is usually 2 to 3 times per day, or as directed by your doctor.
  • The amount applied and the duration of treatment will depend on the specific condition being treated. Typically, the treatment duration should be limited to the shortest time possible to control the symptoms.
  • Always wash your hands before and after applying the medication, unless the treated area is your hands itself.

Side Effects of Fusiderm

Fusiderm, a combination medication containing fusidic acid and betamethasone, can potentially cause side effects. It's important to note that not everyone will experience these side effects, and the severity can vary from person to person. Common side effects of Fusiderm might include:

Fusidic Acid-related side effects:

  • Skin irritation: This can include redness, itching, burning, or stinging at the application site.
  • Allergic reactions: While rare, some individuals may experience allergic reactions such as rash, swelling, or hives.

Betamethasone-related side effects:

  • Skin thinning: Long-term use of corticosteroids like betamethasone can lead to thinning of the skin, making it more fragile and susceptible to bruising and tearing.
  • Skin discoloration: Prolonged use may cause the treated skin to become lighter or darker than the surrounding skin.
  • Increased hair growth: Some individuals may notice increased hair growth in the treated area.
  • Delayed wound healing: Corticosteroids can slow down the healing process of wounds and cuts.
  • Contact dermatitis: In some cases, prolonged use of corticosteroids can lead to a skin condition called contact dermatitis, which causes redness, itching, and inflammation.

If you experience severe or unexpected side effects while using Fusiderm, such as signs of an allergic reaction (difficulty breathing, swelling of the face or throat, severe rash), it's important to seek medical attention immediately.

Interaction with other drugs

Fusiderm, which contains fusidic acid and betamethasone, may interact with other medications, substances, or medical conditions. Here are a few potential interactions to be aware of:

  • Other Topical Medications: Using multiple topical medications simultaneously on the same area of skin can increase the risk of side effects, particularly if they contain corticosteroids.
  • Systemic Corticosteroids: If you are already taking oral corticosteroids (such as prednisone) or other systemic corticosteroids, there is a potential for an increased risk of side effects when using a topical corticosteroid like betamethasone.
  • Other Medications: While Fusiderm is primarily applied topically, it's still important to discuss any other medications you are taking with your doctor to ensure there are no potential interactions, especially if you have a history of allergies, sensitivities, or other medical conditions.
  • Immunosuppressants: If you are taking medications that suppress the immune system (such as immunosuppressive drugs for organ transplant patients), using topical corticosteroids like betamethasone might affect the immune response.

What to avoid while on Fusiderm

While using Fusiderm, there are certain precautions and things to avoid to ensure the safety and effectiveness of the treatment. Here are some guidelines to follow:

  • Avoid Overuse: Prolonged or excessive use of corticosteroids like betamethasone can lead to skin thinning, increased risk of side effects, and other issues.
  • Avoid Applying to Sensitive Areas: Unless specifically instructed by your doctor, avoid applying Fusiderm to sensitive areas such as the face, groin, or around the eyes. These areas are more prone to side effects from corticosteroids.
  • Avoid Abrasive or Harsh Skin Products: While using Fusiderm, avoid using abrasive or harsh skin products that might further irritate the skin.
  • Avoid Using Multiple Topical Medications: Using multiple topical medications on the same area of skin simultaneously can increase the risk of side effects and interactions. If you're using other topical treatments, discuss this with your doctor to determine the best approach.
  • Avoid Allergic Reactions: If you experience any signs of an allergic reaction, such as itching, redness, swelling, or rash, discontinue the use of Fusiderm and seek medical attention.
  • Avoid Sun Exposure: Some topical medications, including corticosteroids, can make your skin more sensitive to the sun. If you're using Fusiderm, it's a good idea to minimize sun exposure and use sunscreen with a high SPF when going outdoors.
  • Avoid Contact with Eyes: Be cautious to avoid getting Fusiderm in your eyes. If accidental contact occurs, rinse your eyes thoroughly with water and seek medical attention if irritation persists.
  • Avoid Sharing Medication: Do not share your medication with others, even if they have similar skin conditions. Medications should be used is tailored to each individual's needs.
  • Avoid Abruptly Stopping Medication: If your doctor has prescribed a specific duration of treatment with Fusiderm, follow their instructions. Abruptly stopping corticosteroids can sometimes lead to a rebound effect or worsening of symptoms.
  • Avoid Self-Medication: Fusiderm is a prescription medication, so it should only be used under the supervision and guidance of a healthcare provider. Avoid using it without proper medical evaluation and prescription.

Contraindications of Fusiderm

Fusiderm, a combination medication containing fusidic acid and betamethasone, has certain contraindications, which are situations or conditions in which the medication should not be used due to the potential risks outweighing the benefits. Here are some contraindications to be aware of:

  • Hypersensitivity or Allergy: If you have a known hypersensitivity or allergy to any of the active ingredients in Fusiderm or any other components of the medication, you should not use it. Allergic reactions can range from mild irritation to severe and potentially life-threatening reactions.
  • Skin Infections Caused by Non-Susceptible Organisms: Fusiderm is effective against certain bacterial strains, particularly Staphylococcus species. If your skin infection is caused by bacteria that are not susceptible to fusidic acid, using Fusiderm may not be effective.
  • Viral or Fungal Infections: Medicine is specifically designed to treat bacterial infections. It should not be used to treat viral infections (such as cold sores or herpes) or fungal infections.
  • Tuberculosis of the Skin: Remedy should not be used to treat skin infections associated with tuberculosis.
  • Perioral Dermatitis: This is a skin condition characterized by redness and bumps around the mouth. The use of topical corticosteroids like betamethasone can worsen perioral dermatitis, so Fusiderm should be avoided in such cases.
  • Skin Atrophy or Thinning: If you have a history of skin atrophy (skin thinning) or fragility, the use of corticosteroids like betamethasone can exacerbate these conditions.
  • Skin Ulcers or Wounds: Using corticosteroids on open skin ulcers or wounds can delay wound healing and increase the risk of infection.
  • Children and Infants: Fusiderm should generally be avoided in children under the age of 2 years.
  • Systemic Absorption Concerns: If you have conditions that might increase the absorption of corticosteroids, such as large areas of damaged skin, the medication may have a greater systemic effect, potentially leading to side effects.

Pregnancy and Fusiderm

Pregnant individuals should exercise caution when using any medication, including topical ones, as the safety of the fetus is a primary concern. Here are some important points to consider:

  • Limited Data: There is limited clinical data available on the use of Fusiderm during pregnancy. This lack of data makes it challenging to determine its safety for pregnant individuals and their developing fetuses.
  • Corticosteroids: Fusiderm contains betamethasone, which is a corticosteroid. While topical corticosteroids are generally considered safer than systemic ones during pregnancy, they should be used with caution and under medical supervision. Long-term or high-dose use of corticosteroids can potentially lead to complications.
  • Risk-Benefit Assessment: The decision to use Fusiderm during pregnancy involves assessing the potential risks to the fetus against the benefits of treating the skin condition.
  • Avoidance During First Trimester: Many doctors advise avoiding unnecessary medication use during the first trimester, which is a critical period of fetal development. If possible, non-pharmacological treatments may be recommended instead.
  • Skin Absorption: While topical medications are generally less likely to reach the bloodstream in significant amounts compared to oral medications, there is still a possibility of some absorption. This is something to consider, especially when using a combination medication.
  • Breastfeeding: If you are breastfeeding, it's important to consider the potential transfer of medications to the baby through breast milk. Discuss the safety of Fusiderm while breastfeeding with your healthcare provider.
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